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GSH is synthesized from cysteine, glutamate, and glycine by the ATP-dependent enzyme -glutamyl-cysteine (-GC) ligase (GCL) synthetase, which is composed of the -GC ligase catalytic subunit (GCLC), the -GC modifier subunit (GCLM), and GSH synthetase (GSS) 24

The most commonly observed irAEs, particularly in treatments combining immune checkpoint inhibitors with chemotherapy, include arthralgia, thyroid dysfunction (both hypothyroidism and hyperthyroidism), transaminitis, dermatologic toxicities, pneumonitis, and colitis

Briefly, cells were incubated with 500 M BP for 1 h

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For instance, DTCs from indolent prostate cancer secrete acidic and cysteine-rich secretory proteins to indirectly trigger the activation of MSC-derived BMP7, which in turn activates dormancy-related signaling pathways in DTCs, such as p38, MAPK and p21 [41]