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Hierarchical clustering of commonly engaged proteins by the fold increase in target engagement in senescent versus non-senescent conditions (referred to as senescence selectivity) identified broadly highly-reactive proteins, clusters of proteins with specificity to certain chemotypes and others (such as GPX4) that were enriched in probes related to three different SCLAs (Fig

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The key experimental findings supporting this mechanism are summarized in the table below: The following tables detail the methodologies from key experiments investigating this compound's effects

Sixteen samples with declared hCG were tested

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Why we boil it: Boiling water zaps away most of the tiny living things that could mess with our experiments