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+-More strikingly, the findings suggest that GPX4 plays a crucial role in preserving intestinal homeostasis by protecting against lipid peroxidation, as evidenced by the increased vulnerability of IEC Gpx4 mice to DSS-induced colonic inflammation relative to their wild-type counterparts (65)

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For people with type 2 diabetes, especially those with microvascular complications, boosting glutathione levels could help mitigate the harmful effects of oxidative stress and slow down the progression of complications

The dashed line shows the distal border of the injury site