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Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease: lessons from animal studies

10.1536/ihj.23.623 Jpn

188 Conversely, asprosin, interleukin-6 (IL-6), TNF-, and IL-12p70, which are predominantly secreted by visceral adipose tissue, 189 impair insulin signaling in muscle and liver and drive non-alcoholic fatty liver disease 190 via pro-inflammatory mechanisms