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doi:10.1016/j.otc.2020.03.015

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By integrating high-dimensional imaging analysis at single-cell resolution, in-depth mechanistic dissection, extensive therapeutic studies in defined preclinical models, and CTC-based correlative studies associated with a Phase Ib clinical trial, this investigation highlights therapy-induced cellular diversification, exposes the 3 BCL-2-upreulated CRPC subtypes with varying AR expression and signaling intensity (i.e., AR + BCL-2 + , AR -/lo BCL-2 + , and AR cyto BCL-2 + ), advances our mechanistic understanding of AR-mediated repression and ARPI-triggered activation of BCL-2 transcription, and, critically, validates BCL-2 as a therapeutic target across distinct CRPC subtypes

Key Features Research Use Only (RUO) compound 50 mg per capsule for consistent research measurement 60 capsules per bottle Encapsulated format for ease of handling in laboratory settings Manufactured and packaged for research applications Product Specifications Compound Name: 5-Amino-1MQ Form: Capsules Dosage Strength: 50 mg per capsule Bottle Size: 60 capsules Grade: Research Use Only (RUO) Intended Use This product is intended solely for laboratory research and investigational purposes