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In melanocytes, depending on the type of kinase and cell line, so far it has been proven that kinases play a dual role in Nrf2 activity regulation, e.g., increased activity of JNK (c-Jun N-terminal kinase) enhances Nrf2 expression in melanocytes line PIG1 but reducing its activation PIG3V cells 69

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It involves initial permeabilization of the mitochondrial outer membrane, followed by an abrupt change in inner membrane permeabilization allowing exit of molecules less than 1500 daltons [89,90]

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30 This finding shows that PR may be an effective regimen in humans and that it may delay aging by influencing the insulin/IGF-1 signaling pathway, an evolutionarily conserved mechanism that regulates longevity