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Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cells

Zha et al., 2025

Both areas are separated by a long ATAAA repetitive stretch, which probably acts as an insulator to separate different epigenetic states such as methylation of the CGIs ( Figure 1