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These data demonstrate that metformin alters metabolism, specifically inhibiting oxidative phosphorylation, and induces significant mitochondrial dysfunction in both HCT116 and SW837 cells, supporting its metabolic modulatory effects in CRC in vitro

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J Neurosci 2006

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Nevertheless, the precise process of maintaining this link is not yet known

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[DOI] [PubMed] [Google Scholar] Yan CC, Huxtable RJ

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