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More importantly, after long-term CCl4 treatment in Nrf2 gene knockout mice, liver fibrosis was severely intensified, and inflammation increased (Xu et al., 2008)

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Col1a1 fl-stop-fl-DTR mice were crossed with Lrat Cre mice, which express Cre in HSCs in the liver, to generate Lrat Col1a1-DTR mice

It has been used initially to restore CFTR function for G551D, the most common class III mutation, although its efficacy has been demonstrated for other less common mutations (such as G1244E, G1349D, G178R, G551S, S1251N, S1255P, S549N, and S549R) (Ponzano et al., 2018

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doi: 10.1007/BF00994344 26 McleanL.HurstJ