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According to manufacturer studies, this ingredient has demonstrated the following benefits: Visible anti-wrinkle effect around the eye area (in vivo) Enhanced colony-forming efficiency of epidermal stem cells (in vitro) Improved ability of skin cells to regenerate and build new tissues in a 3D epidermis model (in vitro) Increased skin density (in vitro) Boosted vitality of epidermal stem cells (in vitro) Reversal of cellular aging signs in fibroblasts (in vitro) Centella Asiatica Extract (Centella) is one of the most researched botanical extracts in skincare with decades of studies backing its effects on inflammation, collagen, and the skin barrier

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Biological Activity In Vitro Polygonatine A, isolated from Polygonatum sibiricum rhizomes, is characterized as 3-hydroxymethyl-5,6,7,8-tetrahydroindolizin-8-one with a molecular formula of C 9 H 11 NO 2 , and defined UV, IR, MS, and NMR spectral profiles [1]

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Furthermore, the vaccine for SARS-CoV-2 was found to be less effective in obese individuals compared with healthy-weight individuals (Ealey et al., 2021)

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