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The effect of protein concentration on the assay's accuracy was also investigated

Generating and injecting SCCNVs from B16F10 senescent cancer cells, induced by doxorubicin treatment, alter significantly by slowing down tumor progression but also in a lung metastasis model by limiting tumor development

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10.1093/nar/gkaf428 112 McLaughlinK.SeagoJ.RobinsonL.KellyC.CharlestonB

10.1016/j.jare.2021.01.001 61 PatilasC.VarsamosI.GalanisA.VavourakisM.ZachariouD.MarougklianisV.et al (2024)

If cellular assays are predictive of potential toxicity, the use of animal models allows the evaluation of toxicity signs occurring in response to the gradual increase in the dose of the substance, considering that the biological response could be species-specific and an active ingredient in animals could be completely inactive in humans