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While TTDS is typically used to evaluate the internal configuration and performance of individual treatment facilities, in this context it extends to an entire industrial cluster functioning as an integrated network of interdependent treatment and production modules

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The resulting ester group may then be hydrolyzed and converted into acyl azide with DPPA, followed by Curtius rearrangement with an alcohol, such as tert-butanol, to provide the corresponding N-Boc protected substrate (not depicted)