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Although they share a high degree of homology, the physiologic roles of these hormones are unique, governed by differences in expression pattern, biopotency, and regulation with LH serving as a key regulator of gonadal steroidogenesis and ovulation, and hCG predominantly active in pregnancy and fetal development

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For primary weight management goals, the clinical evidence points clearly to semaglutide as the standard of care, with tirzepatide representing the most evidence-backed option for those who want greater weight loss

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