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Cell Biol 10, 243257

doi: 10.1016/j.jplph.2014.08.019 149 OsmolovskayaN.ShumilinaJ.KimA.DidioA.GrishinaT.BilovaT.et al

This vulnerability is exploitable both by genetic targeting of the selenocysteine biosynthesis pathway and, notably, through repurposing the FDA-approved agent Auranofin, which disrupts selenium utilisation, induces lipid peroxidation, and demonstrates CNS-specific anti-leukaemic eaicacy with excellent tolerability in vivo

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[20] Note on NAD + reduction The reversible reduction of NAD involves the transfer of two hydrogen atoms from the substrate, the aldehyde group of glyceraldehyde 3-phosphate undergoing oxidation: one as a hydride ion (2 e + H + ) to the nicotinamide ring, and the other as a free proton released into solution