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Inhibiting the expression of iron response element binding protein 2 (IREB2), the main transcription factor of iron metabolism, can significantly increase the expression of FTL and FTH1, thereby inhibiting ferroptosis induced by erastin 28

Histological examination of liver tissue plays a crucial role in confirming the diagnosis, excluding alternate or comorbid etiologies, distinguishing AIH from ASC/overlap syndrome, and assessing fibrosis stage for prognostication

Studies demonstrate protection against ischemia, Alzheimer's pathology, and age-related cognitive decline through direct CNS effects

Trends Immunol 43(1):7892

These findings clarify the competitive relationship between glutamine in tumor cells and nontumor cells, which may be a potential target for future clinical treatment