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This discrepancy highlights a key consideration for translational applications: while voluntary exercise naturally boosts irisin and may offer neuroprotective benefits, patients with neurodegenerative diseases such as Parkinsons often experience mobility limitations that restrict sustained physical activity 35

Myocardial reperfusion injury exacerbation due to ALDH2 deficiency is mediated by neutrophil extracellular traps and prevented by leukotriene C4 inhibition

doi: 10.1136/gut.44.6.886 10 RatnerM

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Samson Osuntokun O, Grace Akingboye B, Olayiwola G et al (2021) The impairment of motor coordination following chronic carbamazepine-levetiracetam combination treatment with evidence of corticocerebellar toxicity in male Wistar rats