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However, it was not recognized at the time that evidence for the protein binding hypothesis was obtained in animals on a normal diet whereas the LPO hypothesis was derived from animals fed a vitamin E-deficient diet high in polyunsaturated fatty acids (PUFAs), i.e., in animals highly susceptibility to LPO [61]

10.1021/jm401540f 89 MpakaliA.SaridakisE.GiastasP.MabenZ.SternL

Additionally, quercetin can upregulate pyroptosis-related genes (GSDMD, GSDME, cleaved CASP1, NLRP3) and activate the pyroptosis pathway to suppress cell proliferation (85)

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In the skin, vitamin C plays a critical role in synthesizing collagen, the protein that provides structure and elasticity

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