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Several FDA-approved medications, such as sorafenib, salazosulfapyridine (SAS), and acetaminophen, have been demonstrated to induce ferroptosis in a variety of cancerous and non-cancerous cell types by inhibiting the system Xc or GSH [130,131,132]

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Some other downstream genes regulated by Nrf2 may be related to cell-to-cell interactions, and the close cooperation and interactions between astrocytes, oligodendrocytes, microglia, and neurons are the basis for maintaining the function of the central nervous system and the normal life activities of living organisms

Mu Q, et al

(2002) Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice