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Apparently, any perturbations in maintaining homeostatic mechanisms in response to changes in oxygen levels are critical in determining cellular characteristic integrity

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[DOI] [PubMed] [Google Scholar] 33.Baranano DE, Rao M, Ferris CD, Snyder SH

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We failed to genetically eliminate either RNF4, or VHL, or both using CRISPER/CAS9 gene editing, and all the surviving cells were escapers expressing both RNF4 and VHL (Supplementary Fig

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