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Mitochondrion-targeting drugs can induce tumor mtDNA oxidation and release to the cytoplasm, activate the cGAS-STING pathway, while mitochondrion Lipid peroxidation and ROS can also promote mtDNA release

The second stage is completed by glutathione synthetase (GS), whose substrate -Glu-Cys undergoes peptide bond condensation with glycine, accompanied by the hydrolysis of ATP to provide the required reaction energy

Nat Commun 15 , 1733 (2024)

Glycocalyx heparan sulfate cleavage promotes endothelial cell angiopoietin-2 expression by impairing shear stress-related AMPK/FoxO1 signaling

Its then sieved and transferred to a washing pond, before being hand-washed over a mesh-screen, ensuring that only pure spirulina is processed

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