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2015 Oct 1 [cited

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Targeting HSPs in autoimmune diseases HSP90 inhibition and inflammatory control HSP90 inhibitors have shown notable immunomodulatory activity in preclinical autoimmune models, consistent with the role of HSP90 in stabilizing signaling proteins that amplify immune activation

References Machicado JD, Gougol A, Tan X, Gao X, Paragomi P, Pothoulakis I, et al

The interaction of the p53-DBD with the Bax RE results in DNA deformation, and its partial disordering around the spacer regions allows p53-DBD to unwind and compress this region to promote proteinprotein interactions