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Interestingly, an E-box motif has also been identified in the rat GCLC promoter, but it is present in the region that negatively regulate the GCLC promoter in lung epithelial L2 cells (Cheng et al., 2005)

This inflammation can lead to pigmentation issues, particularly in individuals prone to post-inflammatory hyperpigmentation

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[1] Catalytic mechanism of phosphopentose isomerase The catalytic mechanism of phosphopentose isomerase resembles that of phosphohexose isomerase (EC 5.3.1.9), a glycolytic enzyme