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Therapeutic Use Exemptions (TUEs) Athletes with legitimate medical reasons for using a prohibited substance or method must apply for a Therapeutic Use Exemption (TUE)

For example, inhibition of respiration leads to a transcriptional switch in the expression of TCA cycle genes in fission yeast to replenish TCA cycle metabolites that support anabolic pathways (Liu and Butow, 1999)

However, comparing semaglutide to tirzepatide reveals that both compounds still benefit from refrigerated storage

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DSIP differs from more pathway-specific compounds such as Epitalon and Orexin in that it does not act through a single defined receptor or molecular axis