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Shanmugam et al., 2015

Suppression of the TORC1 gene in nematodes activates SKN-1 and DAF-16, thereby increasing stress resistance and lifespan

0.13 micromoles/liter) (97)

In the blood, about 80% of cobalamin is bound to haptocorrin, forming holohaptocorrin, a complex that has a dual function: (1) holohaptocorrin conveys cobalamin to the liver, where it taken up through endocytosis (mediated by asialoglycoprotein receptor, ASGPR)