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The authors documented that the extracts lead to an increase in the level of GABA in the brain, especially in INH and PTZ models, which could be the possible mechanism of the extract (Alshabi et al., 2022)
doi: 10.1016/j.plefa.2018.11.002 228 SavardJMoussaHPelletierJFJulienPLacombeLTiguertRet al
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LCS-1 inhibition of superoxide dismutase 1 induces ROS-dependent death of glioma cells and degradates PARP and BRCA1
This review aims to systematically expound on these dual physiological and pathological roles, arguing that such disease-specific metabolic alterations not only provide biomarkers but, more importantly, unveil targetable vulnerabilities, thereby positioning amino acid metabolism as a strategic frontier for developing novel therapeutics across liver diseases
