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Moreover, inhibiting BH4 caused a worsening of colitis.[ref] A cell study of lupus patients showed that eNOS mRNA was increased compared to healthy controls, but they had reduced nitric oxide production

You can think of proteins as a full-length necklace, while peptides are like short strands of that same chain

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Therefore, while existing evidence supports low local toxicity, comprehensive in vitro and in vivo immunogenicity testing remains advisable prior to clinical translation [71, 191]