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GlyNAC Improved Sensitivity to Thermal Pain in SCI Rats in the Short Term The differences in thermal and mechanical pain responses between rats in the SCI and GlyNAC+SCI groups and those in the control group are shown in Fig

doi: 10.1038/s41418-019-0482-7 175 CornelissenTSpinazziMMartinSImberechtsDVangheluwePBirdMet al

GAA is an aldosterone-type triterpenoid derived from Ganoderma lucidum, known for its antioxidant, anti-inflammatory, antidepressant, and anticancer properties ( In vitro experiments confirmed that A 25-35 treatment significantly inhibited the activation of the NRF2/SLC7A11/GPX4 signaling pathway in HT22 cells, upregulated the expression of Fe 2+ , TFR1, ACSL4, MDA, and GSSG, and decreased the expression of FTH1, SOD, and GSH, as well as the GSH/GSSG ratio, resulting in dysregulated neuronal iron metabolism, impaired amino acid antioxidant systems, mitochondrial dysfunction, and ferroptosis, which ultimately promoted neuronal injury

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