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National Health Service (2022)

indeed, higher circulating IGF-I concentrations are positively associated with a number of health parameters related to body composition and cardiovascular health, and negatively associated with body fat [3]

Frontiers in physiology

A groundbreaking 2019 study demonstrated that colonizing ALS mice with Akkermansia muciniphila (a mucin-degrading bacterium usually considered pro-inflammatory in PD/MS contexts) actually ameliorated ALS progression in the mice [83]