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TH regulation is a particularly intricate example of feedback control: dopamine (the first catecholamine product) binds the Fe center in the TH active site, and this binding stabilizes an interaction between the N-terminal regulatory domain -helix (containing Ser40) and the catalytic domain, physically occluding the substrate binding site and preventing both L-DOPA synthesis and dopamine egress

10.1016/S2213-2600(13)70286-8 Lancet Respir Med

It detoxifies by facilitating transport of toxins out of the body

Patients often see benefits in a little as a few weeks, while others see results within two to three months of beginning their regimen

Progress in neurobiology 33 , 87134 (1989)