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161 Further, cytosolic GOT1 inhibition decreases oxaloacetate levels and reduces the cellular NADPH/NADP + and GSH/GSSG ratios

Mathematical modeling of retinal degeneration: Aerobic glycolysis in a single cone

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10.1038/labinvest.2008.75 92 YamamotoM.KenslerT

PMID: 11115795

The excessive ROS production during reperfusion can lead to the opening of the mitochondrial permeability transition pore (mPTP), causing mitochondrial swelling, loss of membrane potential, and cell death [2]