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Furthermore, the Hexachlorobenzene pesticide, which was widely used until 1965, through the activation of the integrin-linked kinase (ILK) signaling, modulates the expression of E-cadherin, which plays an important role in BBB dysfunction, facilitating the leukocytes massive influx into the brain parenchyma, which in turn induces irreversible demyelination, tissue damage, and axonal dysfunction ( The organic solvents precise effect on DNA methylation warrants further investigation but is known that in MS patients the immune regulatory gene protein tyrosine phosphatase (SHP)1 promoter region is highly methylated, facilitating the immune cell infiltration into the brain (Kumagai et al., 2012)

Sci Rep 11:9397 Pavia CS, Plummer MM (2020) Clinical implications of nicotine as an antimicrobial agent and immune modulator

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