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After obtaining thalidomide-based electrophiles, they reacted on-bead with five-amine-containing kinase inhibitors via a direct condensation reaction, in the presence of DIPEA

In the SURPASS clinical trial program in type 2 diabetes mellitus (T2D), tirzepatide was associated with unprecedented reductions in HbA1c, clinically significant weight loss and other metabolic benefits, combined with low rates of hypoglycaemia across a wide range of patient characteristics