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Cell Mol Immunol

revealed that inhibiting the 15LOX-2/PEBP1 complex, even without directly targeting 15-LOX, can reduce the production of 15-hydroperoxy-eicosatetraenoyl phosphatidylethanolamine (15-HpETE-PE), thereby effectively suppressing lipid peroxidation and ferroptosis ( in vitro and in vivo by specifically targeting the 15LOX-2/PEBP1 complex, which has become a critical target in ferroptosis research (Dar et al., 2023)

Sikiri P, Petek M, Rucman R, Seiwerth S, Grabarevi Z, Rotkvi I, et al

Selenium Deficiency-Induced Pancreatic Pathology Is Associated with Oxidative Stress and Energy Metabolism Disequilibrium

A narrative synthesis was performed to organize and interpret the search findings

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