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In further embodiments, the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulates intracellular NAD+ levels to provide muscular therapy

doi: 10.1016/0005-2760(74)90188-x

In controlled laboratory research environments, NNMT activity is associated with nicotinamide metabolism, cellular energy balance, and biochemical signaling networks

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Can injectable vitamins be combined with other treatments

It's important to avoid retinoids and certain oral medications