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Abbreviations AD: Alzheimers disease AMPK: AMP-activated protein kinase APOE: Apolipoprotein E APP/PS1E9: Amyloid precursor protein/presenilin 1 E9 ATP: Adenosine triphosphate A: Amyloid-beta BBB: Blood-brain barrier BCL-2: B-cell lymphoma 2 BCL-XL: B-cell lymphoma-extra large CAR-T: Chimeric antigen receptor T-cell CDK5: Cyclin-dependent kinase 5 CNS: Central nervous system DNA: Deoxyribonucleic acid DRI: D-Retro-Inverso FOXO4: Forkhead box O4 FOXO4-DRI: FOXO4-D-Retro-Inverso fMRI: Functional magnetic resonance imaging GSK3: Glycogen synthase kinase 3 beta IL-1: Interleukin-1 beta IL-6: Interleukin-6 IND: Investigational New Drug JNK: C-Jun N-terminal kinase MCI: Mild cognitive impairment MoCA: Montreal Cognitive Assessment MRI: Magnetic resonance imaging OPCs: Oligodendrocyte precursor cells PARP: Poly (ADP-ribose) polymerase ROS: Reactive oxygen species SASP: Senescence-associated secretory phenotype TNF-: Tumor necrosis factor- 3xTg-AD: Triple transgenic Alzheimers disease References Abou Zaki R, El-Osta A (2024) Metformin: decelerates biomarkers of aging clocks

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In lupus, NF-kB is constitutively activated in multiple immune cell types, driving the persistent inflammatory state that characterizes the disease

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Corticosteroids, particularly when combined with local anaesthetic (which is common), are toxic to all our musculoskeletal tissues

This process allows repair cells to traverse long cellular distances and organize at injury points