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When 5-ALA is administered exogenously, one of its deriving porphyrinsprotoporphyrin IX (PpIX)preferentially accumulates in the intracellular compartment of tumor cells due to decreased levels of ferrochelatase and selective uptake by an ATP-binding cassette transporter (ABCB6) [120]

Starting at the lower end of dosing ranges (20-30 mcg) and assessing response before increasing is advisable

American Association for Cancer Research:46, 2005

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Frequency: Typically, it is injected once or twice a week

R.SongG.GaoT.MaJ.HanX.HuM.-W.et al (2023)