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2 B12 deficiency can be due to inadequate dietary intake, in particular in people following a strict vegan diet (B12 is only found in animal foods)

Biomaterials 35 , 814824 (2014)

GLP-1 activation reduces how hungry you feel

It has been suggested that the enzymes in coffee stimulate bile excretion [13], which if true suggests that a coffee enema may prevent dark bile fluid accumulation in the distal small bowel