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B12 absorption occurs primarily through an intrinsic factor-dependent mechanism in the terminal ileum

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These findings establish -syn as a key regulator of neuronal ferroptosis and highlight ether-PLs as potential therapeutic targets in synucleinopathies (Mahoney-Sanchez et al., 2022)

A pharmacokinetic (PK) and pharmacodynamic (PD) analysis of the antioxidants used in these trials suggests that many inconclusive results may reflect pharmacokinetic limitations rather than true pharmacodynamic inefficacy