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Adrenal Insufficiency: Adrenal insufficiency has been reported with opioid use

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Inhibition of cell cycle progression by hydroxytyrosol is associated with upregulation of cyclin-dependent protein kinase inhibitors p21 WAF1/Cip1 and p27 Kip1 and with induction of differentiation in HL60 Cells

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The cells were then stained with DAPI, mounted on a slide, and imaged using a confocal microscope with 40 (oil) immersion objective (Zeiss LSM 980, Carl Zeiss)

doi: 10.1046/j.1365-2141.1996.d01-1730.x 116 CastielloMCBosticardoMSacchettiNCalzoniEFontanaEYamazakiYet al