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Early concerns about stem cells potentially becoming cancerous have not been borne out in clinical practice, though long-term data collection continues

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The translocator proteingene is associated with endogenous pain modulation and the balance betweenglutamate and gamma-aminobutyric acid in fibromyalgia and healthy subjects:a multimodal neuroimaging study

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With regular assessment of hematological indices and urinary protein levels as the key monitoring parameter, some protocols recommended periodic measurements of serum B12 to adjust dosing as needed to prevent B12 overdosage which can lead to unnecessarily high serum levels and potential adverse effects such as acneiform eruptions, rash, or gastrointestinal discomfort [42, 43]