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2025 Nov 1 [cited 2025 Nov 24];361:199644

FHM type 2 belongs to migraine with aura, which is associated with spreading depression 328

For example, circRPN2 has been shown to bind to enolase 1 (ENO1), accelerating its degradation

A recent study including spontaneously hypertensive rats and controls (WKY) reported that UA therapy (16 mg/kg) induced Kruppel-like factor 2 (KLF2) expression, lowered vascular endothelial growth factor (VEGF)-A levels, reduced BBB leakage, and improved endothelial cell barrier integrity [194, 196]