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Cytoprotection and Anti-Inflammation It reduces pro-inflammatory cytokines (e.g., TNF-, IL-6) and oxidative stress, protecting tissues from chronic inflammatory damage

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This is shown to have a direct impact on the gut, and the subsequent microbiome-brain axis

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It is mostly believed that DMF exerts its therapeutic effects through antioxidant and anti-inflammatory pathways (Figure 1)

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Seki H, Takayama H, Aimi N, Sakai S, Ponglux D (1993) A nuclear magnetic resonance study of the eleven stereoisomers of heteroyohimbine-type oxindole alkaloids

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