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J Pain Res

doi: 10.1016/j.jphs.2022.11.001 156

Natural bioactive compounds (polyphenols) enhance detoxification capacity by upregulating GST expression and promoting glutathione biosynthesis (3436)

Furthermore, GSH plays an essential role in the glutathione-ascorbate cycle, facilitating the reduction of hydrogen peroxide (HO)a highly reactive oxidant that, if not neutralized, can damage lipids, proteins, and DNA (48)