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However, a major hurdle for such free small-molecule drugs is their rapid clearance from the articular cavity and short half-life, which necessitates frequent injections and often results in suboptimal therapeutic bioavailability [38, 39]

and as an ingredient in topical preparations for wound healing

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Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice

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