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High doses of riboflavin (400 mg) have demonstrated potential effectiveness for adult migraine prevention (76)

Following a reported death in November 2024 associated with the high dose, Neurogene will proceed with the trial using only the low dose (www.neurogene.com)

Yes, hyperthyroidism can affect the skin in several ways: Hyperpigmentation (melasma): Hormonal shifts, such as increased ACTH, may lead to darker patches of skin Excess sweating and rashes: Heat rashes often appear in skin folds due to higher sweat production Pretibial myxedema: A rare condition where the skin on the shins or tops of the feet becomes red, thickened, and swollen Associated autoimmune conditions: People with Graves disease may also develop vitiligo (loss of skin pigment) or alopecia areata (patchy hair loss) Functional medicine treatment considers both the thyroid imbalance and its skin manifestations, helping reduce symptoms and improve overall wellbeing

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