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At present, most evidence regarding ECM remodeling derives from studies in general MAFLD or hepatic fibrosis

Ahmed O, King NE, Qureshi MA, Choudhry AA, Osama M, Zehner C, Ali A, Hamzeh IR, Palaskas NL , Thompson KA, Koutroumpakis E, Deswal A, Yusuf SW

This effect is associated with inhibited oncogenic activity of AKT and MYC, as well as Bax phosphorylation, suggesting that PP2A may also be a potential metformin target in lung cancer therapy

Research protocols studying these broad gene expression effects, tissue repair, or anti-aging biomarkers typically use the injectable route