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AAV2-mediated delivery of the GDNF gene (NCT04167540) and the AXO-Lenti-PD vector for dopamine synthesis (NCT03720418) are being evaluated for their potential to restore dopaminergic neuron function and alleviate motor symptoms

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Finally, other activation mechanisms contribute to the activation of the NLRP3 inflammasome, further aiding in the development of PD models in animals (Huang et al., 2024