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Nicotinamide N-methyltransferase (NNMT) is a cytoplasmic enzyme that catalyzes the methylation of nicotinamide (NAM) with the methyl donor S-adenosyl-methionine (SAM) to form methylnicotinamide (MNAM) and S-adenosyl-l-homocysteine (SAH) (Alston and Abeles, 1988

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The absence of Wnt signalling inhibits the nuclear transport of -catenin mediated by ZBP1, resulting in a decrease in Runx2 and Sp7 (osteogenic factors) expression in mouse bone marrow-derived MSCs