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Supplements can affect oxidative stress markers, including glutathione levels

eLife 6 , e24437 (2017)

The 2024 fusion-peptide work exists precisely because researchers recognized that native DSIPs delivery to the brain is the bottleneck, and engineered around it by fusing DSIP to a blood-brain-barrier-crossing TAT transduction domain (sequence GGGGYGRKKRRQRRR) via flexible GGGGS linkers, expressed and secreted from Pichia pastoris

Activation of G protein-coupled estrogen receptor 1 at the onset of reperfusion protects the myocardium from I/R injury by decreasing mitophagy through the PINK1/Parkin pathway [104]