interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Dual inhibition of carbonic anhydrase
Dual inhibition of carbonic anhydrase IX and glutathione peroxidase 4 as a novel strategy for ferroptosis induced tumor cell death ScienceDirect Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines Journal of Medicinal Chemistry The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities Discovery of novel benzylaniline derivatives containing chloroacetamide as GPX4 inhibitors with potential efficacy in triple negative breast cancer ScienceDirect Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S Transferase Pi 1 Inhibition by the Anti cancer Compound Piperlongumine* Journal of Biological Chemistry An Activity Guided Map of Electrophile Cysteine Interactions in Primary Human T Cells ScienceDirect
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![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Dual inhibition of carbonic anhydrase](https://ars.els-cdn.com/content/image/1-s2.0-S0223523425008724-ga1.jpg)
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![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Dual inhibition of carbonic anhydrase](https://ars.els-cdn.com/content/image/1-s2.0-S0092867420308230-gr4.jpg)